Search on: 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES 
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Descriptor English:   3-Phosphoinositide-Dependent Protein Kinases 
Descriptor Spanish:   Proteínas Quinasas Dependientes de 3-Fosfoinositido 
Descriptor Portuguese:   Proteína Quinases Dependentes de 3-Fosfoinositídeo 
Tree Number:   D08.811.913.696.620.682.700.745
Definition English:   Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the production of the SECOND MESSENGERS, phosphatidylinositol 3,4,-biphosphate (PtdIns(3,4)P2) and phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3). 
History Note English:   2014 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   55307 
Unique Identifier:   D064413 

Occurrence in VHL: 		 

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